To submit your revised manuscript, the highlighted version (with changes marked) must be uploaded as the "Highlighted File" without any author identification. Please delete the original anonymized manuscript from the previous stage and replace it with the newly revised files. Additionally, if a response to the reviewers is required, it should be uploaded as a separate "Response to Reviewers" file. Alternatively, any necessary explanations for the reviewers may be included at the beginning of the "Highlighted File,"